What Is Cellulite? Dimpled Skin Texture, Causes & Treatment Options

What Is Cellulite? Dimpled Skin Texture, Causes & Treatment Options

What Is Cellulite? Dimpled Skin Texture, Causes & Treatment Options

Cellulite is a common dimpled, lumpy, or uneven skin texture that appears when fat beneath the skin pushes against connective-tissue bands, making the surface look puckered or orange-peel-like.

Cellulite is not cellulitis, not an infection, and not a sign of poor hygiene. This page covers appearance, locations, causes, risk factors, diagnosis, treatment options, realistic expectations, supportive habits, myths, and medical warning signs.

What Is Cellulite and Why Does Skin Look Dimpled?

Cellulite is a common dimpled, lumpy, or uneven skin texture that appears when fat beneath the skin pushes against connective-tissue bands, making the surface look puckered or orange-peel-like.

The texture comes from the structure under the skin, not from dirt, hygiene, toxins, or a lack of effort.

Fat compartments, fibrous bands, connective tissue, skin thickness, hormones, genetics, and skin laxity all influence how visible the dimples become.

Why Is Cellulite Not the Same as Cellulitis?

Cellulite is a skin-texture concern, while cellulitis is a bacterial skin infection.

Cellulite means dimpling, puckering, or orange-peel texture. Cellulitis can cause warmth, swelling, pain, spreading redness, fever, pus, or a person feeling unwell.

Confusing the two can delay infection care, so sudden hot painful swollen skin should not be treated as ordinary cellulite.

Why Is Cellulite Common and Not a Hygiene Problem?

Cellulite is common and is not caused by dirt, toxins, or poor hygiene.

It can happen in people of many body sizes and fitness levels, including people who are slim or physically fit.

Body structure, sex-related connective-tissue patterns, hormones, genetics, skin laxity, and fat distribution matter more than personal blame.

Scientific graphic showing fat compartments and fibrous bands creating cellulite dimples A clean scientific process graphic showing fat layer, fibrous bands, skin surface tension, dimples, puckering, and visible cellulite texture. Fat-Band-Dimple Mechanism fat layer fibrous bands surface tension dimples Fat layer + fibrous bands + skin surface tension → dimples / puckering → visible cellulite texture Scientific graphic: cellulite is a structural texture pattern, not an infection. skinkeeps.com
Figure 1. Cellulite forms when fat compartments, fibrous bands, and skin-surface tension create visible dimples.

Practical rule: Cellulite care should focus on realistic texture improvement and safety checks, not shame or guaranteed erasure.

What Does Cellulite Look Like on Skin?

Cellulite usually looks like dimples, puckering, lumpiness, rippling, or orange-peel texture on the skin surface.

It may be mild and visible only when standing, squeezing the skin, or viewing in side lighting, or it may be more visible at rest.

What Are the Common Cellulite Texture Patterns?

Common cellulite texture patterns include small dimples, puckered depressions, orange-peel texture, cottage-cheese texture, and uneven rippling.

Some dimples look round and tethered. Others look like a soft uneven surface across the thighs, buttocks, hips, abdomen, or upper arms.

The skin color is often normal unless another condition is present.

What Symptoms Are Not Typical for Cellulite?

Fever, spreading warmth, severe pain, pus, sudden one-sided swelling, rapid redness, open sores, blue-black skin, or hard painful lumps are not typical cellulite symptoms.

These signs should trigger medical evaluation rather than cosmetic treatment.

Ordinary cellulite does not cause a person to feel feverish, ill, or suddenly unable to use a limb normally.

How Can Cellulite Visibility Change?

Cellulite visibility can change with lighting, posture, skin laxity, weight change, age, and how the skin is squeezed or stretched.

Standing may show more texture than lying down, and side lighting can make dimples look deeper.

Skin laxity, weight gain, weight loss, pregnancy, aging, or hormonal shifts can change how noticeable the texture appears.

FeatureTypical Cellulite ClueWhen to Check
TextureDimpled, puckered, lumpy, rippled.Painful hard lump.
ColorUsually normal skin color.Red, hot, blue, black, bruised.
SensationUsually not painful.Pain, tenderness, fever.
PatternOften gradual and in common areas.Sudden one-sided swelling.
CourseLong-standing or slowly changing.Rapid change, open sore, pus.

Where Does Cellulite Usually Appear?

Cellulite most often appears on the thighs, buttocks, hips, abdomen, and upper arms, although it can appear anywhere subcutaneous fat and connective tissue create visible dimpling.

It may be more visible on the outer thighs, back of thighs, lower belly, buttocks, hips, and areas where skin laxity or fibrous tethering affects the surface.

Location helps recognition, but pain, swelling, warmth, sudden change, or one-sided enlargement should broaden the diagnosis.

AreaWhy Cellulite May Show ThereMimic to Consider
ThighsCommon fat distribution and fibrous bands.Lipedema if painful, heavy, or bruised.
ButtocksTethered dimples may be visible.Scar tissue or localized volume loss.
HipsBody-shape and fat distribution pattern.Loose skin or stretch marks.
AbdomenSkin laxity, fat distribution, weight change.Hernia, edema, or skin laxity if unusual.
Upper armsSkin laxity and subcutaneous fat.Lymphedema if swollen or heavy.
CalvesLess classic; evaluate if swollen or painful.Edema, vascular disease, lipedema.

What Causes Cellulite?

Cellulite develops from structural changes under the skin, especially the way fat cells, fibrous connective bands, skin thickness, circulation, hormones, and genetics interact.

It is not simply “fat” and not simply “loose skin.” It is a visible texture pattern created by multiple tissue layers.

How Do Fibrous Bands Create Dimples?

Fibrous bands create dimples when they pull the skin downward while nearby fat compartments push upward.

These connective-tissue bands, also called fibrous septae, can tether the skin to deeper tissue.

When the band pulls down and surrounding tissue pushes up, the surface can look puckered, dimpled, or mattress-like.

How Do Fat Distribution and Skin Thickness Affect Cellulite?

Fat distribution and skin thickness affect cellulite because dimpling becomes more visible when subcutaneous fat, skin laxity, and thinner or less elastic skin interact.

Weight loss may improve visibility in some people, but it can also reveal skin laxity in others.

Slim people can still have cellulite because fibrous bands, hormones, genetics, and skin structure still matter.

How Do Hormones and Genetics Affect Cellulite?

Hormones and genetics affect cellulite by influencing fat distribution, connective-tissue structure, skin thickness, circulation, and how easily dimples become visible.

Cellulite is more common in women, partly because of differences in fat distribution and connective-tissue architecture.

Aging and reduced skin elasticity can also make the same underlying texture more noticeable.

Scientific graphic showing structural causes of cellulite A clean scientific cause map showing fibrous bands, fat compartments, skin laxity, genetics, hormones, and fluid shifts as contributors to cellulite texture. Cellulite Cause Matrix cellulite visible texture fibrous bands fat compartments skin laxity hormones / genes Scientific graphic: cellulite is multifactorial, so one simple fix rarely fits every pattern. skinkeeps.com
Figure 2. Cellulite visibility is shaped by fibrous bands, fat compartments, skin laxity, hormones, genetics, and tissue architecture.
Cause FactorHow It Affects TextureTreatment Implication
Fibrous bandsPull skin downward.Subcision or laser may target bands.
Fat compartmentsPush upward.Body composition may affect visibility.
Skin laxityShows dimples more.Skin-tightening may help selected cases.
GeneticsInfluences tissue and fat pattern.Not fully preventable.
HormonesInfluence fat and connective tissue.Explains common female pattern.
Fluid shiftsMay change texture temporarily.Massage effects may be temporary.

Who Is More Likely to Have Cellulite?

Cellulite is more likely in women, adults, people with genetic tendency, areas with certain fat distribution, and skin that has become thinner or less elastic with age.

These are context factors, not blame factors. Cellulite can appear in active, fit, slim, curvy, post-pregnancy, older, or younger adult bodies.

  • Female-pattern fat and connective-tissue structure.
  • Family history.
  • Hormonal changes.
  • Puberty or adulthood.
  • Skin laxity.
  • Aging skin.
  • Body-composition changes.
  • Areas with more subcutaneous fat.
  • Pregnancy-related or hormonal shifts.
  • Sedentary habits that reduce muscle tone.
  • Fit or slim body type can still show cellulite.

How Is Cellulite Different From Other Skin or Leg Conditions?

Cellulite is a surface texture pattern, while conditions like cellulitis, lipedema, lymphedema, edema, varicose veins, stretch marks, and loose skin have different causes and treatment needs.

This distinction matters because ordinary dimpling is cosmetic, while pain, swelling, warmth, fever, bruising, or one-sided limb change can be medical.

How Is Cellulite Different From Cellulitis?

Cellulite means dimpling, while cellulitis means infection.

Cellulitis can be painful, warm, swollen, red, feverish, spreading, and medically urgent.

Cellulite does not cause fever or a spreading hot painful skin infection.

How Is Cellulite Different From Lipedema?

Lipedema can cause painful, symmetrical fat enlargement, tenderness, easy bruising, heaviness, and disproportionate legs or arms, while cellulite is mainly surface dimpling.

Lipedema and cellulite can coexist, which can make the surface look lumpy.

Painful swelling, easy bruising, leg heaviness, or disproportionate limb enlargement should not be dismissed as cosmetic cellulite.

How Is Cellulite Different From Lymphedema or Edema?

Lymphedema and edema involve swelling or fluid buildup, while cellulite is a dimpled texture without sudden fluid swelling.

Edema may pit when pressed, and lymphedema may cause chronic heaviness, tightness, swelling, or limb-size change.

Sudden one-sided leg swelling needs medical evaluation, especially if pain, redness, chest pain, or shortness of breath occurs.

How Is Cellulite Different From Stretch Marks or Loose Skin?

Stretch marks are linear streaks, loose skin is laxity or sagging, and cellulite is dimpling or puckering.

These patterns can overlap after pregnancy, weight change, aging, or skin laxity.

Rare connective-tissue loose skin disorders such as cutis laxa are different from ordinary cellulite and need their own medical evaluation when suspected.

ConditionMain ClueWhy Confusion HappensSafer Next Step
CelluliteDimpled texture.Common thigh or buttock change.Cosmetic discussion if desired.
CellulitisWarm painful infection, fever possible.Similar word.Urgent medical care.
LipedemaPainful symmetrical fat, heaviness, bruising.Lumpy legs overlap.Medical evaluation.
LymphedemaChronic swelling or heaviness.Limb texture changes.Lymph or vascular review.
EdemaPitting or swelling.Skin looks uneven.Check cause.
Stretch marksLinear streaks.Texture change overlap.Skin-laxity care.
Loose skinSagging folds.Dimples can look worse.Skin-tightening discussion.

How Is Cellulite Diagnosed?

Cellulite is usually diagnosed by looking at the skin texture, body area, symmetry, and whether the change is a long-standing dimpled surface rather than pain, swelling, warmth, or infection.

Most classic cellulite does not need lab tests or imaging. Diagnosis changes when red flags are present.

What Does a Clinician Check?

A clinician checks cellulite by looking at the location of dimples, whether they appear standing or when the skin is pinched, skin laxity, fat distribution, and whether warning signs are present.

The exam may also review weight-change history, pregnancy history, pain, swelling, bruising, warmth, redness, leg heaviness, lumps, infection signs, procedure history, and cosmetic goals.

Clear treatment goals matter before choosing any procedure.

When Are Tests Usually Not Needed?

Tests are usually not needed for classic long-standing cellulite dimpling without pain, swelling, fever, warmth, sudden one-sided change, hard mass, or open sore.

A stable surface texture in common sites is usually a clinical appearance diagnosis.

Testing becomes more relevant when swelling, infection, vascular disease, lipedema, lymphedema, hard lumps, or sudden change is possible.

When Should Diagnosis Broaden Beyond Cellulite?

Diagnosis should broaden beyond cellulite when the skin change is new, painful, swollen, warm, one-sided, bruised, hard, infected-looking, or rapidly changing.

Leg heaviness, easy bruising, numbness, non-healing sores, fever, unexplained weight loss, or systemic symptoms also change the safety picture.

Shortness of breath or chest pain with leg swelling needs urgent evaluation.

Scientific clinical pathway for cellulite recognition and red flags A clean scientific pathway showing dimpled texture, common location, no pain or swelling, likely cosmetic cellulite, and medical evaluation when red flags are present. Clinical Texture Pathway dimpled texture common site no red flags? likely cellulite evaluate Dimpled texture → common location and symmetry → no pain/fever/swelling? → cosmetic cellulite likely → red flags? → medical evaluation Scientific graphic: classic cellulite is clinical; sudden pain, swelling, fever, or one-sided change changes the diagnosis. skinkeeps.com
Figure 3. Cellulite diagnosis is usually visual when dimpling is stable, symmetric, and not painful, swollen, warm, feverish, or sudden.

What Treatment Options Can Improve Cellulite?

Cellulite treatments may improve the appearance of dimples, but most options reduce visibility rather than permanently remove cellulite.

The best plan depends on the main driver: tethered fibrous bands, skin laxity, surface quality, fat distribution, or fluid-related texture.

Which Professional Treatments Have Better Evidence?

Professional cellulite treatments with stronger support include subcision, laser-assisted approaches, acoustic wave therapy, radiofrequency-based treatments, and vacuum-assisted tissue release for selected cellulite patterns.

Results vary by cellulite type, skin laxity, provider skill, procedure choice, and treatment plan.

Cosmetic procedures should be discussed with a qualified dermatologist, plastic surgery specialist, or trained medical professional.

What Should Users Know About Subcision?

Subcision targets fibrous bands beneath dimples, so it may help selected tethered cellulite depressions.

It is not ideal for every cellulite pattern. Discrete tethered dimples may fit better than broad laxity or swelling-driven texture.

Bruising, soreness, uneven results, recurrence, and procedure risks should be discussed before treatment.

What Should Users Know About Laser, Radiofrequency, and Acoustic Wave Therapy?

Laser, radiofrequency, and acoustic wave therapies may improve cellulite appearance by targeting fibrous bands, skin tightening, collagen support, or tissue texture in selected cases.

Laser-assisted approaches may target bands and skin thickness. Radiofrequency may support tightening in selected cases. Acoustic wave therapy may improve appearance after a treatment course.

Results are variable, not guaranteed, and maintenance may be needed.

Do Creams, Caffeine, Retinol, and Massage Help Cellulite?

Creams, caffeine, retinol, and massage may make cellulite look slightly better for some people, but the results are usually modest or temporary.

Caffeine products may temporarily change surface appearance. Retinol may support surface quality over time in some users. Massage can shift fluid temporarily.

Topicals and massage do not cut fibrous bands or permanently change the deeper structural tethering.

Treatment OptionBest-Fit UseExpected ResultKey Caution
SubcisionTethered dimples.Can improve selected dimples.Procedure risk; provider skill matters.
Laser-assisted subcisionFibrous bands + texture.Improvement in selected patients.Cost, bruising, side effects.
Acoustic wave therapyTexture improvement.Often requires a treatment course.Variable duration.
RadiofrequencyCellulite + mild laxity.Smoothing or tightening support.Not an eraser.
Vacuum-assisted releaseTethered bands.Dimple release.Bruising or soreness possible.
Retinol/caffeine creamsMild surface improvement.Modest or temporary effect.Ongoing use may be needed.
Massage devicesFluid/texture temporarily.Short-term improvement.Maintenance needed.
LiposuctionFat removal, not cellulite treatment.Not recommended for cellulite alone.May worsen dimpling.

What Lifestyle Habits Can Make Cellulite Less Noticeable?

Lifestyle habits may make cellulite less noticeable by supporting muscle tone, skin health, circulation, and body composition, but they do not guarantee cellulite removal.

Strength training can improve muscle tone under the skin, and regular movement can support circulation and body composition.

Balanced nutrition, gradual weight management when relevant, smoking avoidance, moisturizing for surface comfort, hydration for general skin function, and sun protection can support skin quality. Dry skin care may improve surface feel, but it does not remove deeper cellulite structure.

  • Strength train for muscle tone.
  • Move regularly.
  • Eat a balanced diet.
  • Avoid crash dieting.
  • Maintain weight gradually if weight changes affect texture.
  • Avoid smoking.
  • Moisturize for surface comfort.
  • Use sun protection for skin quality.
  • Keep expectations realistic.

Can Cellulite Be Permanently Removed?

Cellulite usually cannot be permanently removed with a single cream, massage, detox, or workout, but some treatments can improve its appearance for months or longer in selected people.

Cellulite is structural and multifactorial, so one approach rarely fits every pattern.

Procedures may improve specific dimples, but results vary, maintenance may be needed, weight loss alone does not guarantee improvement, and liposuction is not a cellulite treatment.

ClaimReality Check
“Cream removes cellulite forever.”Usually false.
“Weight loss always fixes cellulite.”Not guaranteed.
“Fit people do not have cellulite.”False.
“Procedures can improve dimples.”Sometimes true.
“Results are permanent for everyone.”Unrealistic.
“Treatment should match cellulite type.”True.
“Liposuction fixes cellulite.”Not recommended as cellulite treatment.

What Cellulite Treatment Mistakes Should You Avoid?

The biggest cellulite mistake is expecting a detox, wrap, cream, or one-time device session to permanently erase a structural skin texture.

Do not confuse cellulite with cellulitis, buy toxin-removal claims, expect spot fat loss to erase dimples, overuse harsh scrubs, use unregulated injections, or choose a procedure without asking what structure it targets.

Do not compare normal skin texture to edited photos, and do not ignore pain, swelling, warmth, fever, bruising, hard lumps, open sores, or one-sided changes.

MistakeWhy It FailsBetter Action
“Detox” treatmentsCellulite is structural, not toxin buildup.Use evidence-aware options.
Cream-only expectationsCreams do not cut fibrous bands.Expect modest results.
Liposuction for dimplesMay worsen texture.Ask for a cellulite-specific plan.
Ignoring red flagsCould be infection, edema, lipedema, or clot risk.Medical review.
Harsh scrubbingIrritates skin.Gentle skin care.
DIY injectionsInfection and scarring risk.Avoid unregulated treatment.
Edited-photo comparisonCreates unrealistic goals.Compare to real baseline photos.

When Should Dimpled or Lumpy Skin Be Checked by a Doctor?

Dimpled skin should be checked by a clinician when it changes suddenly, becomes painful, swollen, warm, red, bruised, one-sided, hard, infected-looking, or associated with fever, leg heaviness, numbness, or rapid limb-size change.

Medical review is also important before cosmetic procedures when there are pregnancy, clotting, immune, infection, healing, swelling, or medication-safety concerns.

Which Signs Suggest This Is Not Ordinary Cellulite?

Signs that suggest something beyond ordinary cellulite include fever, spreading warmth, severe pain, one-sided swelling, sudden leg enlargement, hard painful lumps, easy bruising, open sores, pus, blue-black skin, numbness, or shortness of breath with leg swelling.

Ordinary cellulite is usually a surface texture change, not sudden illness, infection, fluid swelling, or limb emergency.

Chest pain or shortness of breath with leg swelling needs urgent care.

Who Should Get Medical Advice Before Cosmetic Cellulite Treatment?

Medical advice before cosmetic cellulite treatment is especially important for people who are pregnant, have clotting history, active infection, uncontrolled diabetes, poor wound healing, blood-thinner use, lymphedema or lipedema symptoms, autoimmune disease, immune suppression, or unexplained pain or swelling.

Procedures that break bands, heat tissue, use needles, or affect deeper layers need trained assessment.

A safe plan should match the person’s health history, skin type, cellulite pattern, and realistic goals.

Seek medical review if there is:

  • Sudden change.
  • One-sided swelling.
  • Pain or tenderness.
  • Warmth.
  • Spreading redness.
  • Fever.
  • Hard painful lump.
  • Easy bruising.
  • Open sore or pus.
  • Blue or black skin.
  • Leg heaviness or tightness.
  • Numbness or weakness.
  • Rapid limb-size change.
  • Shortness of breath or chest pain with leg swelling.
  • Active infection before any cosmetic procedure.
  • Clotting history, blood thinners, poor wound healing, or uncontrolled diabetes before procedure.

What Should You Remember About Cellulite?

Cellulite is a common dimpled skin texture, so the safest approach is to understand the structure, avoid myths, choose realistic treatment options, and check medical red flags instead of chasing a guaranteed cure.

Texture improvement is possible for selected people, but the best choice depends on the dimple pattern, skin laxity, health history, and treatment goal.

  • Cellulite is common and harmless for most people.
  • It is dimpled skin texture, not cellulitis.
  • It is not caused by toxins, dirt, or poor hygiene.
  • It often affects thighs, buttocks, hips, abdomen, and upper arms.
  • It forms from fat compartments, connective bands, skin thickness, hormones, genetics, and skin laxity.
  • Treatments can improve appearance but usually do not permanently erase cellulite.
  • Procedures like subcision, laser, acoustic wave therapy, and radiofrequency may help selected cases.
  • Cellulite creams and massage may offer modest or temporary improvement.
  • Pain, fever, warmth, sudden swelling, hard lumps, bruising, or one-sided changes need medical review.

Frequently Asked Questions About Cellulite

Is cellulite a disease?

Cellulite is usually a harmless skin-texture condition rather than a disease or infection. It can still bother people cosmetically, and treatment goals should stay realistic.

What does cellulite look like?

It may look like dimpled, lumpy, puckered, orange-peel, rippled, or cottage-cheese-like skin texture, especially on thighs, buttocks, hips, abdomen, or upper arms.

What causes cellulite?

Cellulite forms through the interaction between fat beneath the skin, fibrous connective bands, skin thickness, hormones, genetics, skin laxity, and tissue structure.

Can thin or fit people have cellulite?

Yes. Cellulite can occur in thin or fit people because skin structure, connective tissue, hormones, genetics, and fat distribution matter.

Is cellulite the same as cellulitis?

No. Cellulite is dimpled texture; cellulitis is a bacterial infection that can cause warmth, swelling, pain, redness, and fever and needs medical care.

What is the best treatment for cellulite?

There is no one best treatment for every case. Treatment depends on whether dimples are driven mainly by tethered fibrous bands, skin laxity, fat distribution, or fluid-related texture. Options may include subcision, laser, acoustic wave therapy, radiofrequency, topical products, or supportive lifestyle habits.

Do cellulite creams work?

Creams may give modest or temporary improvement, especially products that affect surface texture, but they do not permanently remove the deeper structural causes of cellulite.

Is liposuction a good cellulite treatment?

No. Liposuction is not recommended as a cellulite treatment because it removes deeper fat rather than correcting the tethering and surface texture pattern, and it may make dimpling more noticeable.

When should “cellulite” be checked by a doctor?

Medical review is needed for sudden one-sided swelling, pain, warmth, redness, fever, hard painful lumps, open sores, pus, bruising, leg heaviness, numbness, rapid change, blue-black skin, or chest pain or shortness of breath with leg swelling.

Sources & Evidence About Cellulite

Mayo Clinic — Cellulite Symptoms & Causes was used for cellulite as a common, harmless condition causing lumpy or dimpled flesh and for common sites including thighs, hips, buttocks, and abdomen.

Mayo Clinic — Cellulite Diagnosis & Treatment was used for diagnosis by skin assessment and the principle that available approaches may improve appearance at least temporarily.

American Academy of Dermatology — Cellulite Treatments was used for treatment options including laser treatment, subcision, acoustic wave therapy, vacuum-assisted tissue release, radiofrequency, creams/lotions, and liposuction caution.

Cleveland Clinic — Cellulite was used for cellulite definition, distinction from cellulitis, causes, all-body-type framing, and supportive lifestyle expectations.

DermNet — Cellulite was used for cellulite as dimpling and lumpiness on the skin surface and for cosmetic rather than physically harmful framing.

PMC — Cellulite: Current Understanding and Treatment was used for multifactorial pathophysiology involving subcutaneous fat, fibrous septae, microcirculation, and skin architecture.

PMC — Treatment for Cellulite was used for evidence discussion around subcision, acoustic wave therapy, radiofrequency, light/laser approaches, and other treatment modalities.

American Society for Dermatologic Surgery — Cellfina was used for tissue-stabilized guided subcision as an FDA-cleared cellulite dimple-improvement device for buttocks and thighs, as an example rather than a product endorsement.

Educational Disclaimer: This SkinKeeps article is for educational purposes only and does not diagnose or replace medical care. Cellulite is usually a harmless cosmetic skin-texture pattern, but sudden, painful, warm, red, swollen, one-sided, bruised, hard, infected-looking, pus-filled, blue-black, numb, rapidly changing, open-sore, fever-associated, leg-heaviness-associated, or chest-pain/shortness-of-breath-associated skin or limb changes should be checked by a qualified healthcare professional. Cosmetic cellulite procedures should be discussed with a trained medical professional, especially for people who are pregnant, have active infection, clotting history, uncontrolled diabetes, poor wound healing, blood-thinner use, immune suppression, lymphedema or lipedema symptoms, autoimmune disease, or unexplained pain or swelling.

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